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Beta BlockersConcomitant therapy with beta-adrenergic blockers and verapamil may result in additive negative effects on heart rateatrioventricular conductionand/or cardiac contractilityThe combination of sustained-release verapamil and beta-adrenergic blocking agents has not been studiedHoweverthere have been reports of excessive bradycardia and AV blockincluding complete heart blockwhen the combination has been used for the treatment of hypertensionFor hypertensive patientsthe risks of combined therapy may outweigh the potential benefitsThe combination should be used only with caution and close monitoring.
ISOPTIN regularly reduces the total systemic resistanceafterloadagainst which the heart works both at rest and at a given level of exercise by dilating peripheral arterioles.
This medication passes into breast milkbut is unlikely to harm a nursing infantConsult your doctor before breast-feeding.
FlecainideA study of healthy volunteers showed that the concomitant administration of flecainide and verapamil may have additive effects on myocardial contractilityAV conductionand repolarizationConcomitant therapy with flecainide and verapamil may result in additive negative inotropic effect and . prolongation of atrioventricular conduction.
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