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Lincocin should be used with caution in patients with a history of asthma or significant allergies.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of LINCOCIN and other antibacterial drugsLINCOCIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Impairment of fertility was not observed in male or female rats given oral 300mg/kg doses of lincomycin0.36 times the highest recommended human dose based on mg/m 2
Cross resistance has been demonstrated between clindamycin and lincomycinResistance is most often due to methylation of specific nucleotides in the 23S RNA of the 50S ribosomal subunitwhich can determine cross resistance to macrolides and streptogramins BMLS B phenotypeMacrolide-resistant isolates of these organisms should be tested for inducible resistance to lincomycin/clindamycin using the D-zone test or other appropriate method.
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