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Information about Lariam
Always take this medicine exactly as your doctor has told youCheck with your doctor if you are not sureThe advice you are given will depend on whether you are taking the tablets for prevention or treatment of malariaTake the tablets with plenty of waterand preferably after a mealSwallow the tablets wholedo not suck or chew them.
In certain casesegwhen a traveler is taking other medicationit may be desirable to start prophylaxis 2 to 3 weeks prior to departurein order to ensure that the combination of drugs is well toleratedsee PRECAUTIONSDrug Interactions
NotePatients with acute Pvivax malariatreated with Lariamare at high risk of relapse because Lariam does not eliminate exoerythrocytichepatic phaseparasitesTo avoid relapse after initial treatment of the acute infection with Lariampatients should subsequently be treated with an 8-aminoquinoline derivativeegprimaquine
Parenteral studies in animals show that mefloquinea myocardial depressantpossesses 20of the anti-fibrillatory action of quinidine and produces 50of the increase in the PR interval reported with quinineThe effect of mefloquine on the compromised cardiovascular system has not been evaluatedHowevertransitory and clinically silent ECG alterations have been reported during the use of mefloquineAlterations included sinus bradycardiasinus arrhythmiafirst degree AV-blockprolongation of the QTc interval and abnormal T wavessee also cardiovascular effects under PRECAUTIONSDRUG INTERACTIONS and ADVERSE REACTIONSThe benefits of Lariammefloquinetherapy should be weighed against the possibility of adverse effects in patients with cardiac disease.
Start taking the medicine 1 to 3 weeks before entering an area where malaria is commonContinue taking the medicine once weekly during your stay and for at least 4 weeks after you leave the area.
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