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In controlled clinical trialssingle doses of 5 and 10 mg of . rizatriptan were effective for the acute treatment of migraines in adultsThere is evidence that the 10mg dose may provide a greater effect than the 5mg doseIndividuals may vary in response to doses of rizatriptan tabletsThe choice of dose of RIZACT Tablets shouldthereforebe made on an individual basisweighing the possible benefit of the 10mg dose with the potential risk for increased undesirable effects.

Factors that trigger this headache type are a muscle strainstress or anxiety.

Angio-oedemae.gfacial oedematongue swelling and pharyngeal oedemamay occur in patients treated with triptanssuch as rizatriptanIf angio-oedema of the tongue or pharynx occursthe patient should be placed under medical supervision until the symptoms have resolvedTreatment should promptly be discontinued and replaced by an agent belonging to another class of drugs.

Undesirable effects may be more common during concomitant use of triptans5-HT 1B1D agonistsand herbal preparations containing StJohn’s wort.

Rizatriptan is not an inhibitor of the activities of human liver CYP450 isoforms3A4/51A22C92C19 or 2E1rizatriptan is a competitive inhibitorKi=1,400 nMof CYP450 2D6but only at highclinically irrelevant concentrations.

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