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Increases in serum potassium concentrationincluding hyperkalemiahave been reported with use of NSAIDseven in some patients without renal impairmentIn patients with normal renal functionthese effects have been attributed to a hyporeninemichypoadosteronism state.
Consider alternative management in patients who are poor CYP2C9 metabolizers.
There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID . useThe concurrent use of aspirin and an NSAIDsuch as celecoxibincreases the risk of serious gastrointestinalGIeventssee Gastrointestinal BleedingUlcerationAnd Perforation
Advise females of reproductive potential who desire pregnancy that NSAIDsincluding CELEBREXmay be associated with a reversible delay in ovulationsee Use In Specific Populations
No information is available from controlled clinical studies regarding the use of CELEBREX in patients with advanced renal diseaseThe renal effects of CELEBREX may hasten the progression of renal dysfunction in patients with preexisting renal disease.
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