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Liver functionAllopurinol may reduce liver function and can cause liver failureIf you have liver problemsdiscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is neededYour doctor may want to test your liver function regularly with blood tests while you are taking this medication.
Zyloprim is a structural analogue of the natural purine basehypoxanthineIt is an inhiboitor of xanthine oxidasethe enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acidthe end product of purine metabolism in manZyloprim is metabolized to the corresponding xanthine analogueoxipurinolalloxanthinewhich also is an inhibitor of xanthine oxidase.
Since the excretion of oxipurinol is similar to that of urateuricosuric agentswhich increase the excretion of urateare also likely to increase the excretion of oxipurinol and thus lower the degree of inhibition of xanthine oxidaseThe concomitant administration of uricosuric agents and Zyloprim has been associated with a decrease in the excretion of oxypurineshypoxanthine and xanthineand an increase in urinary uric acid excretion compared with that observed with Zyloprim aloneAlthough clinical evidence to date has not demonstrated renal precipitation of oxypurines in patients either on Zyloprim alone or in combination with uricosuric agentsthe possibility should be kept in mind.
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