Among the tested compounds, we found that only promethazine caused a notable reduction 19 of thioflavin s fluorescence signal p 0.
Information about Promethazine.
Do not let anyone else take your medicationAsk your pharmacist any questions you have about refilling your prescription.
Promethazine HClpromethazine hydrochloridemay be used alone or as an adjunct to narcotic analgesics during laborsee DOSAGE AND ADMINISTRATIONLimited data suggest that use of promethazine during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newbornThe effect on later growth and development of the newborn is unknownSee also Nonteratogenic Effects
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant SyndromeNMShas been reported in association with promethazine HClpromethazine hydrochloridealone or in combination withantipsychotic drugsClinical manifestations of NMS are hyperpyrexiamuscle rigidityaltered mental status and evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresis and cardiac dysrhythmiasThe diagnostic evaluation of patients with this syndrome is complicatedIn arriving at a diagnosisit is important to identify cases where the clinical presentation includes both serious medical illnesse.gpneumoniasystemic infectionetcand untreated or inadequately treated extrapyramidal signs and symptomsEPSOther important considerations in the differential diagnosis include central anticholinergic toxicityheat strokedrug fever and primary central nervous systemCNSpathology.
To relieve dry mouthsucksugarlesshard candy or ice chipschewsugarlessgumdrink wateror use a saliva substitute.
Since recurrences of NMS have been reported with phenothiazinesthe reintroduction of promethazine HClpromethazine hydrochlorideshould be carefully considered.
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