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Phenylpropanolamine ppa in subjects who had received emsam 6 mg per 24 hours for 9 days, co-administration with ppa 25 mg every 4 hours for 24 hours did not affect the pharmacokinetics of ppa.
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There were no clinically significant changes in blood pressure during pseudoephedrine administration alone, or in combination with emsam see drug interactions .
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Tyramine pressor doses were also studied in 11 subjects after extended treatment with emsam 12 mg per 24 hours.
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