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It may take up to 2 weeks before your cholesterol levels improveKeep using your medication as directedYou will need frequent blood tests to measure your cholesterol levels.
Concurrent administration of ZETIA with a specific statin or fenofibrate should be in accordance with the product labeling for that medication.
Patients have experienced severe muscle problems while taking ZETIAusually when ZETIA was added to a statin drugIf you experience unexplained muscle paintendernessor weakness while taking ZETIAcontact your doctor immediatelyYou need to do this promptlybecause on rare occasionsthese muscle problems can be seriouswith muscle breakdown resulting in kidney damage.
In this limited controlled studythere was no significant effect on growth or sexual maturation in the adolescent boys or girlsor on menstrual cycle length in girls.
Ezetimibe does not inhibit cholesterol synthesis in the liveror increase bile acid excretionInsteadezetimibe localizes at the brush border of the small intestine and inhibits the absorption of cholesterolleading to a decrease in the delivery of intestinal cholesterol to the liverThis causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the bloodthis distinct mechanism is complementary to that of statins and of fenofibratesee Clinical Studies
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